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Article

Evaluation of the use of monoclonal antibodies and nested PCR for noninvasive prenatal diagnosis of hemoglobinopathies in India.

American journal of clinical pathology - 1 Aug 2008

D'Souza Edna, Sawant Pratibha M, Nadkarni Anita H, Gorakshakar Ajit, Mohanty Dipika, Ghosh Kanjaksha, Colah Roshan B

Abstract excerpt

Our purpose was to develop and evaluate isolation and enrichment of fetal erythroblasts and a nested polymerase chain reaction (PCR) approach using fetal erythroblasts for detecting the beta-globin gene mutations for a noninvasive prenatal diagnosis of hemoglobinopathies. Maternal blood at different periods of gestation was layered on a Percoll density gradient for enrichment of fetal nucleated RBCs (NRBCs). A...

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PMID: 18628088
DOI: 10.1309/1WDCPGTAJJ6A938V

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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