Contrasted Blood and Intragraft Toll-Like Receptor 4 mRNA Profiles in Operational Tolerance Versus Chronic Rejection in Kidney Transplant Recipients

Abstract excerpt

BACKGROUND: Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kidney transplant recipients. METHODS: Here, we analyzed the expression of TLR4 in peripheral...

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