Article
Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden.
Thrombosis and haemostasis - 1 Dec 2006
Couturaud Francis, Kearon Clive, Leroyer Christophe, Mercier Bernard, Abgrall Jean Francois, Le Gal Grégoire, Lacut Karine, Oger Emmanuel, Bressollette Luc, Ferec Claude, Lamure Michel, Mottier Dominique
Abstract excerpt
The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE). We aimed to determine the annual incidence of VTE in first-degree relatives of patients with VTE and FVL and to identify factors in patients and the relatives that influence this incidence. In this retrospective and prospective cohort study, the...
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