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Article

Impact of double heterozygosity for Factor V Leiden and Prothrombin G20210A on the thrombotic phenotype.

Thrombosis research - 1 Apr 2021

Luxembourg Beate, Henke Franziska, Kirsch-Altena Anette, Sachs Ulrich, Kemkes-Matthes Bettina

Abstract excerpt

INTRODUCTION: Because of the rarity of double heterozygosity for Factor V Leiden (FVL) and Prothrombin (FII) G20210A, little is known about the thrombotic phenotype in double heterozygotes. MATERIAL AND METHODS: In a retrospective cohort study of patients referred for a thrombophilia work-up, we investigated whether double heterozygotes (n = 138) exhibit a more severe thrombotic phenotype compared with single FVL...

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Identifiers

PMID: 33588106
DOI: 10.1016/j.thromres.2021.01.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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