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Article

No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk.

The Prostate - 15 Sept 2008

Fall K, Stark J R, Mucci L A, Chan J, Stampfer M J, Kurth T, Febbo P G, Kantoff P, Ma J

Abstract excerpt

OBJECTIVE: Insulin receptor substrate-1 (IRS-1) acts as a docking protein between the insulin-like growth factor-1 (IGF-1) receptor and intracellular signaling molecules in the IGF-1 signaling pathway. Accumulating data support a role of IGF-1 in prostate carcinogenesis. We assessed the influence of the most common IRS-1 gene polymorphism (Gly972Arg) on prostate cancer risk, alone and in combination with IGF-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18615538
DOI: 10.1002/pros.20797
PMCID: PMC2958090

Genes

IGFBP3
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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