Article
The impact of prothrombotic mutations on factor consumption in adult patients with severe hemophilia.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Dec 2009
Ar M Cem, Baykara Onur, Buyru Ayse Nur, Baslar Zafer
Abstract excerpt
About 10% of patients with severe hemophilia exhibit a milder clinical phenotype with less frequent bleeds. Among many other factors, coinheritance of prothrombotic mutations have been proposed to act as modulators of clinical severity in severe hemophilia. We conducted a study to evaluate the impact of 3 prothrombotic mutations (factor V Leiden, factor II, and methylenetetrahydrofolate reductase mutations) on...
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