Article
Interpatient phenotypic inconsistency in severe congenital hemophilia: a systematic review of the role of inherited thrombophilia.
Seminars in thrombosis and hemostasis - 1 Apr 2009
Franchini Massimo, Montagnana Martina, Targher Giovanni, Veneri Dino, Zaffanello Marco, Salvagno Gian Luca, Manzato Franco, Lippi Giuseppe
Abstract excerpt
It is well known that the clinical phenotype of hemophilia may vary greatly among patients with the same apparent level of coagulation factor and the same genetic mutation. Thus, patients with severe hemophilia may experience a severe phenotype or only a milder bleeding tendency, suggesting some other moderating influence. To elucidate the mechanism of this heterogeneity, some investigators have recently...
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