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Article

Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9).

Nucleosides, nucleotides & nucleic acids - 1 Jun 2008

Huang Min, Mitchell Beverly S

Abstract excerpt

DHX-9, a member of the DEXH family of RNA helicases, unwinds dsRNA/dsDNA by ATP or GTP-dependent hydrolysis. We asked whether DHX-9 played a role in the GTP depletion-induced inhibition of rRNA synthesis and/or nucleolar disruption. MPA, a specific inhibitor of inosine monophosphate dehydrogenase (IMPDH), induced a rapid translocation of DHX-9 from the nucleolus to the nucleus. EGFP-tagged DHX-9 mutated at the...

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Identifiers

PMID: 18600529
DOI: 10.1080/15257770802145132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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