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Article

A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.

Journal of virology - 1 Oct 2012

Strang Blair L, Bender Brian J, Sharma Mayuri, Pesola Jean M, Sanders Rebecca L, Spector Deborah H, Coen Donald M

Abstract excerpt

Protein-protein interactions are required for many biological functions. Previous work has demonstrated an interaction between the human cytomegalovirus DNA polymerase subunit UL44 and the viral replication factor UL84. In this study, glutathione S-transferase pulldown assays indicated that residues 1 to 68 of UL84 are both necessary and sufficient for efficient interaction of UL84 with UL44 in vitro. We created...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22855486
DOI: 10.1128/JVI.01379-12
PMCID: PMC3457161

Genes

IRS1

Provenance

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