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Article

Metal content of metallo-beta-lactamase L1 is determined by the bioavailability of metal ions.

Biochemistry - 29 Jul 2008

Hu Zhenxin, Gunasekera Thusitha S, Spadafora Lauren, Bennett Brian, Crowder Michael W

Abstract excerpt

In an effort to probe whether the metal content of metallo-beta-lactamase L1 is affected by metal ion bioavailability, L1 was overexpressed as mature protein (M-L1) and full-length (FL-L1) analogues, and the analogues were characterized with metal analyses, kinetics, and EPR spectroscopy. FL-L1, containing the putative leader sequence, was localized in the periplasm of Escherichia coli and shown to bind Zn(II)...

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Identifiers

PMID: 18597493
DOI: 10.1021/bi8004768
PMCID: PMC2750885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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