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Article

Thermodynamic characterization of nucleoplasmin unfolding: interplay between function and stability.

Biochemistry - 29 Jul 2008

Franco Guillermo, Bañuelos Sonia, Falces Jorge, Muga Arturo, Urbaneja María A

Abstract excerpt

The unfolding equilibrium of recombinant (rNP) and natural variants of nucleoplasmin (NP) from Xenopus laevis has been analyzed using biochemical and spectroscopic techniques. In the presence of denaturing concentrations of guanidinium salts (GuHCl and GuSCN), both domains, core and tail, of the rNP pentamer unfold as proven using single-carrying tryptophan mutants, whereas urea is remarkably unable to fully...

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PMID: 18597490
DOI: 10.1021/bi8002555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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