Article
Oral fludarabine and cyclophosphamide as front-line chemotherapy in patients with chronic lymphocytic leukemia. The impact of biological parameters in the response duration.
Annals of hematology - 1 Nov 2008
Laurenti Luca, Tarnani Michela, De Padua Laura, Efremov Dimitar G, Zini Gina, Garzia Mariagrazia, Piccirillo Nicola, Chiusolo Patrizia, Sorà Federica, Innocenti Idanna, Sica Simona, Leone Giuseppe
Abstract excerpt
We tested the efficacy and safety of oral fludarabine and cyclophosphamide as front-line therapy in chronic lymphocytic leukemia (CLL) and assessed the influence of immunoglobulin variable region heavy chain (IgVH) gene mutation status, interphase cytogenetic abnormalities, and expression of ZAP-70 and CD38 on clinical outcome. Thirty-seven patients with previously untreated CLL received oral fludarabine (30 mg...
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