Article
Creating and evaluating genetic tests predictive of drug response.
Nature reviews. Drug discovery - 1 Jul 2008
Weiss Scott T, McLeod Howard L, Flockhart David A, Dolan M Eileen, Benowitz Neal L, Johnson Julie A, Ratain Mark J, Giacomini Kathleen M
Abstract excerpt
A key goal of pharmacogenetics--the use of genetic variation to elucidate inter-individual variation in drug treatment response--is to aid the development of predictive genetic tests that could maximize drug efficacy and minimize drug toxicity. The completion of the Human Genome Project and the associated HapMap Project, together with advances in technologies for investigating genetic variation, have greatly...
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