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Genes for the Biosynthesis of the Fungal Polyketides Hypothemycin from <i>Hypomyces subiculosus</i> and Radicicol from <i>Pochonia chlamydosporia</i>

21 Jun 2008

Abstract excerpt

Gene clusters for biosynthesis of the fungal polyketides hypothemycin and radicicol from Hypomyces subiculosus and Pochonia chlamydosporia, respectively, were sequenced. Both clusters encode a reducing polyketide synthase (PKS) and a nonreducing PKS like those in the zearalenone cluster of Gibberella zeae, plus enzymes with putative post-PKS functions. Introduction of an O-methyltransferase (OMT) knockout...

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PMID: 18567690
DOI: 10.1128/aem.00478-08

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