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Article

Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Alli Rajshekhar, Nguyen Phuong, Geiger Terrence L

Abstract excerpt

The properties of a self-specific T cell's TCR that determine its pathogenicity are not well understood. We developed TCR retroviral transgenic, or retrogenic, models of myelin oligodendroglial glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) to compare the pathologic potential of five H-2 Ab/MOG35-55-specific TCRs. The TCRs were cloned and retrovirally transduced into either...

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Share to Encephalomyelitis, Autoimmune, Experimental
Share to Myelin-Associated Glycoprotein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myelin-Oligodendrocyte Glycoprotein

Share to Myelin Proteins

Share to Receptors, Antigen, T-Cell

Share to Retroviridae

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Source

Open in PubMed Open full text

Identifiers

PMID: 18566378
DOI: 10.4049/jimmunol.181.1.136
PMCID: PMC2615687

Genes

MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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