Article
Refining genetic associations in multiple sclerosis
17 Jun 2008
Abstract excerpt
Genome-wide association studies involve several hundred thousand markers and, even when quality control is scrupulous, are invariably confounded by residual uncorrected errors that can falsely inflate the apparent difference between cases and controls (so-called genomic inflation).1 As a consequence such studies inevitably generate false positives alongside genuine associations. By use of Bayesian logic and...
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