Article
Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations.
Clinical genetics - 1 Aug 2008
Spielmann N, Mutch D M, Rousseau F, Tores F, Hager J, Bertrais S, Basdevant A, Tounian P, Dubern B, Galan P, Clément K
Abstract excerpt
Cathepsin S (CTSS) is a cysteine protease that has a central role in remodeling the extracellular matrix and, as such, has been implicated in the etiology of cardiovascular disease. This study used five tag single nucleotide polymorphisms (tSNPs) to screen the CTSS gene in healthy lean (n = 1891) and obese French populations (n = 477) for their association with various phenotypes: body mass index, waist-to-hip...
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