Article
Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors.
Breast cancer research and treatment - 1 Sept 2009
Bane Anita L, Pinnaduwage Dushanthi, Colby Sarah, Reedijk Michael, Egan Sean E, Bull Shelley B, O'Malley Frances P, Andrulis Irene L
Abstract excerpt
BACKGROUND: BRCA1- and BRCA2-associated tumors appear to have distinct molecular signatures. BRCA1-associated tumors are predominantly basal-like cancers, whereas BRCA2-associated tumors have a predominant luminal-like phenotype. These two molecular signatures reflect in part the two cell types found in the terminal duct lobular unit of the breast. To elucidate novel genes involved in these two spectra of breast...
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