Long-term GH treatment improves adult height in children with Noonan syndrome with and without mutations in protein tyrosine phosphatase, non-receptor-type 11.

Abstract excerpt

CONTEXT: Noonan syndrome (NS) is characterized by short stature, typical facial dysmorphology and congenital heart defects. Short-term effect of GH therapy in NS is beneficial, reports on the effect on adult height are scarce. OBJECTIVE: To determine the effect of long-term GH therapy in children with NS. DESIGN: Twenty-nine children with NS were treated with GH until final height was reached. SETTING: Hospital...

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