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Article

Noonan syndrome: relationships between genotype, growth, and growth factors.

The Journal of clinical endocrinology and metabolism - 1 Jan 2006

Limal Jean-Marie, Parfait Béatrice, Cabrol Sylvie, Bonnet Damien, Leheup Bruno, Lyonnet Stanislas, Vidaud Michel, Le Bouc Yves

Abstract excerpt

CONTEXT: Half of the patients with Noonan syndrome (NS) carry mutation of the PTPN11 gene, which plays a role in many hormonal signaling pathways. The mechanism of stunted growth in NS is not clear. OBJECTIVE: The objective of the study was to compare growth and hormonal growth factors before and during recombinant human GH therapy in patients with and without PTPN11 mutations (M+ and M-). SETTING, DESIGN, AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Like Growth Factor Binding Protein 3

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Source

Identifiers

PMID: 16263833
DOI: 10.1210/jc.2005-0983

Genes

SDS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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