The anomalous effects of biased mutation revisited: mean-optimum deviation and apparent directional selection under stabilizing selection.

Abstract excerpt

Empirical evidence indicates that the distribution of the effects of mutations on quantitative traits is not symmetric about zero. Under stabilizing selection in infinite populations with normally distributed mutant effects having a nonzero mean, Waxman and Peck showed that the deviation of the population mean from the optimum is expected to be small. We show by simulation that genetic drift, leptokurtosis of...

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