Article
Identifying a few foot-and-mouth disease virus signature nucleotide strings for computational genotyping.
BMC bioinformatics - 13 Jun 2008
Lin Guohui, Cai Zhipeng, Wu Junfeng, Wan Xiu-Feng, Xu Lizhe, Goebel Randy
Abstract excerpt
BACKGROUND: Serotypes of the Foot-and-Mouth disease viruses (FMDVs) were generally determined by biological experiments. The computational genotyping is not well studied even with the availability of whole viral genomes, due to uneven evolution among genes as well as frequent genetic recombination. Naively using sequence comparison for genotyping is only able to achieve a limited extent of success. RESULTS: We...
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