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Article

IRES-Mediated Translation of Utrophin A Is Enhanced by Glucocorticoid Treatment in Skeletal Muscle Cells

10 Jun 2008

Abstract excerpt

Glucocorticoids are currently the only drug treatment recognized to benefit Duchenne muscular dystrophy (DMD) patients. The nature of the mechanisms underlying the beneficial effects remains incompletely understood but may involve an increase in the expression of utrophin. Here, we show that treatment of myotubes with 6alpha-methylprednisolone-21 sodium succinate (PDN) results in enhanced expression of utrophin A...

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PMID: 18545658
DOI: 10.1371/journal.pone.0002309

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Related research

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IRES-Mediated Translation of Utrophin A Is Enhanced by Glucocorticoid Treatment in Skeletal Muscle CellsPMID 18545658Read ↗

A Cell-Based High-Throughput Screening Assay for Posttranscriptional Utrophin UpregulationSemantic proximity Read ↗

The effect of glucocorticoids on the accumulation of utrophin by cultured normal and dystrophic human skeletal muscle satellite cellsSemantic proximity Read ↗

Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeuticsSemantic proximity Read ↗

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Local transcriptional control of utrophin expression at the neuromuscular synapse.Semantic proximity Read ↗

Induction of utrophin gene expression by heregulin in skeletal muscle cells: Role of the N-box motif and GA binding proteinSemantic proximity Read ↗

Molecular and Biochemical Therapeutic Strategies for Duchenne Muscular DystrophySemantic proximity Read ↗

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