Article
A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder.
Brain : a journal of neurology - 1 Sept 2007
Bogaerts Veerle, Engelborghs Sebastiaan, Kumar-Singh Samir, Goossens Dirk, Pickut Barbara, van der Zee Julie, Sleegers Kristel, Peeters Karin, Martin Jean-Jacques, Del-Favero Jurgen, Gasser Thomas, Dickson Dennis W, Wszolek Zbigniew K, De Deyn Peter P, Theuns Jessie, Van Broeckhoven Christine
Abstract excerpt
Dementia with Lewy bodies (DLB) represents the second most frequent type of neurodegenerative dementia in the elderly. Although most patients have sporadic DLB, a limited number of DLB families have been described, suggesting that genetic factors may contribute to DLB pathogenesis. Here, we describe a three-generation Belgian family with prominent dementia and parkinsonism, consistent with a diagnosis of DLB,...
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