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BCR‐ABL1‐induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia

5 Jun 2008

Abstract excerpt

In order to determine new signal transduction pathways implicated in chronic myeloid leukaemia (CML), we performed a gene expression profile comparison between CD34+ cells from CML patients and healthy donors. Functional studies were performed using the Mo7e and Mo7e-p210 cell lines. Expression of CCND1 (Cyclin D1), as well as the chaperone HSPA8, which is important for regulation of CCND1, were significantly...

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PMID: 18537972
DOI: 10.1111/j.1365-2141.2008.07221.x

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