HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

doi:10.1038/s41467-018-03627-9

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Article

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

Nature communications - 12 Apr 2018

Sevin Margaux, Kubovcakova Lucia, Pernet Nicolas, Causse Sébastien, Vitte Franck, Villeval Jean Luc, Lacout Catherine, Cordonnier Marine, Rodrigues-Lima Fernando, Chanteloup Gaétan, Mosca Matthieu, Chrétien Marie-Lorraine, Bastie Jean Noël, Audia Sylvain, Sagot Paul, Ramla Selim, Martin Laurent, Gleave Martin, Mezger Valérie, Skoda Radek, Plo Isabelle, Garrido Carmen, Girodon François, de Thonel Aurélie

Abstract excerpt

Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The OGX-427 antisense oligonucleotide against HSP27 has been reported to be beneficial against idiopathic pulmonary fibrosis. Here we show that OGX-427 is effective in two murine models of thrombopoietin- and JAKV617F-induced myelofibrosis. OGX-427 limits...

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Identifiers

PMID: 29650953
DOI: 10.1038/s41467-018-03627-9
PMCID: PMC5897330

Genes

JAK2
HSPB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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