Article
NF-kappaB in the pathogenesis and treatment of multiple myeloma.
Current opinion in hematology - 1 Jul 2008
Li Zhi-Wei, Chen Haiming, Campbell Richard A, Bonavida Benjamin, Berenson James R
Abstract excerpt
PURPOSE OF REVIEW: This review aims to summarize recent advances in the mechanisms through which the activation of the transcription factor NF-kappaB contributes to the pathogenesis of multiple myeloma. RECENT FINDINGS: This transcription factor regulates expression of numerous genes involved in multiple myeloma pathogenesis, including growth, survival, immortalization, angiogenesis and metastasis. Recently,...
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