Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

Cancer cell - 1 Aug 2007

Keats Jonathan J, Fonseca Rafael, Chesi Marta, Schop Roelandt, Baker Angela, Chng Wee-Joo, Van Wier Scott, Tiedemann Rodger, Shi Chang-Xin, Sebag Michael, Braggio Esteban, Henry Travis, Zhu Yuan-Xiao, Fogle Homer, Price-Troska Tammy, Ahmann Gregory, Mancini Catherine, Brents Leslie A, Kumar Shaji, Greipp Philip, Dispenzieri Angela, Bryant Barb, Mulligan George, Bruhn Laurakay, Barrett Michael, Valdez Riccardo, Trent Jeff, Stewart A Keith, Carpten John, Bergsagel P Leif

Abstract excerpt

Activation of NF-kappaB has been noted in many tumor types, however only rarely has this been linked to an underlying genetic mutation. An integrated analysis of high-density oligonucleotide array CGH and gene expression profiling data from 155 multiple myeloma samples identified a promiscuous ar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to CD40 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deubiquitinating Enzyme CYLD

Share to Inhibitor of Apoptosis Proteins

Share to Multiple Myeloma

Share to NF-kappa B p50 Subunit

Share to TNF Receptor-Associated Factor 2

Share to Transmembrane Activator and CAML Interactor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 17692805
DOI: 10.1016/j.ccr.2007.07.003
PMCID: PMC2083698

Genes

TRAF3
CYLD
LTBR
NFKB1
NFKB2
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17692805-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.PMID 17692805Read ↗

Classical and/or alternative NF-kappaB pathway activation in multiple myeloma.Semantic proximity Read ↗

Bi-allelic inactivation is more prevalent at relapse in multiple myeloma, identifying RB1 as an independent prognostic markerSemantic proximity Read ↗

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myelomaSemantic proximity Read ↗

WITHDRAWN: Canonical NF-κB regulator CYLD mutations reinforce RelB mediated disease pathogenesis in Multiple MyelomaSemantic proximity Read ↗

Multiple myeloma: lusting for NF-kappaB.Semantic proximity Read ↗

Frequent Engagement of RelB Activation Is Critical for Cell Survival in Multiple MyelomaSemantic proximity Read ↗

Targeting NF-κB Signaling for Multiple MyelomaSemantic proximity Read ↗

Clinical benefit of ixazomib plus lenalidomide-dexamethasone in myeloma patients with non-canonical NF-κB pathway activation.Semantic proximity Read ↗

Impact of Genetic Polymorphisms in NF-ĸB2 and TRAF3 Genes on Response to Bortezomib-Based Therapy in Multiple Myeloma Patients.Semantic proximity Read ↗

NF-kappaB in the pathogenesis and treatment of multiple myeloma.Semantic proximity Read ↗

Polymorphisms of nuclear factor-κB family genes are associated with development of multiple myeloma and treatment outcome in patients receiving bortezomib-based regimens.Semantic proximity Read ↗

c‐FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.