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Article

Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties.

Virology - 1 Aug 1991

Kool M, Voncken J W, van Lier F L, Tramper J, Vlak J M

Abstract excerpt

Defective interfering particles (DIPs) were generated upon continuous production of Autographa californica nuclear polyhedrosis virus (AcNPV) in bioreactors. This configuration mimicked the serial undiluted passaging of virus, which is known to result in plaque-morphology mutants. Restriction enzyme analysis of DIP-containing preparations of extracellular virus showed the presence of many DNA fragments in less...

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PMID: 1853572
DOI: 10.1016/0042-6822(91)91003-y

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Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties.PMID 1853572Read ↗

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