Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties.

doi:10.1016/0042-6822(91)91003-y

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Article

Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties.

Virology - 1 Aug 1991

Kool M, Voncken J W, van Lier F L, Tramper J, Vlak J M

Abstract excerpt

Defective interfering particles (DIPs) were generated upon continuous production of Autographa californica nuclear polyhedrosis virus (AcNPV) in bioreactors. This configuration mimicked the serial undiluted passaging of virus, which is known to result in plaque-morphology mutants. Restriction enz...

Topics

Animals
Baculoviridae
Base Sequence
Biotechnology
Cell Line
DNA, Viral
Defective Viruses
Lepidoptera
Microscopy, Electron
Molecular Sequence Data
Mutation
Restriction Mapping

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