Article
Improving melanoma classification by integrating genetic and morphologic features.
PLoS medicine - 3 Jun 2008
Viros Amaya, Fridlyand Jane, Bauer Juergen, Lasithiotakis Konstantin, Garbe Claus, Pinkel Daniel, Bastian Boris C
Abstract excerpt
BACKGROUND: In melanoma, morphology-based classification systems have not been able to provide relevant information for selecting treatments for patients whose tumors have metastasized. The recent identification of causative genetic alterations has revealed mutations in signaling pathways that offer targets for therapy. Identifying morphologic surrogates that can identify patients whose tumors express such...
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