Article
In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.
Molecular cancer therapeutics - 1 Jun 2008
Ikediobi Ogechi N, Reimers Mark, Durinck Steffen, Blower Paul E, Futreal Andrew P, Stratton Michael R, Weinstein John N
Abstract excerpt
The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. We previously sequenced 24 cancer genes in those cell lines. Eleven of the genes were found to be mutated in three or more of the lines. Using a pharmacogenomic approach, we analyzed the relationship between drug activity and mutations in those 11 genes (APC,...
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