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Article

Differential expression of cytokine genes and iNOS induced by nonviable nontypeable Haemophilus influenzae or its LOS mutants during acute otitis media in the rat.

International journal of pediatric otorhinolaryngology - 1 Aug 2008

Tong Hua Hua, Chen Yiping, Liu Xia, DeMaria Thomas F

Abstract excerpt

OBJECTIVE: We have previously demonstrated that the disruptions of nontypeable Haemophilus influenzae (NTHi) lipooligosaccharide (LOS) htrB and rfaD genes may play a role in the pathogenesis of otitis media (OM). The purpose of this study was to determine whether NTHi LOS gene disruptions influence the induction of gene expression for proinflammatory mediators in vivo using the rat model of acute OM. METHODS: At...

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Source

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Identifiers

PMID: 18524391
DOI: 10.1016/j.ijporl.2008.04.007
PMCID: PMC2601687

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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