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Article

Probe-specific mixed-model approach to detect copy number differences using multiplex ligation-dependent probe amplification (MLPA).

BMC bioinformatics - 4 Jun 2008

González Juan R, Carrasco Josep L, Armengol Lluís, Villatoro Sergi, Jover Lluís, Yasui Yutaka, Estivill Xavier

Abstract excerpt

BACKGROUND: MLPA method is a potentially useful semi-quantitative method to detect copy number alterations in targeted regions. In this paper, we propose a method for the normalization procedure based on a non-linear mixed-model, as well as a new approach for determining the statistical significance of altered probes based on linear mixed-model. This method establishes a threshold by using different tolerance...

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Identifiers

PMID: 18522760
DOI: 10.1186/1471-2105-9-261
PMCID: PMC2492880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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