Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy.

Biochemical and biophysical research communications - 8 Aug 2008

Wang Jianwei, Wang Hu, Chen Jingzhou, Wang Xiaojian, Sun Kai, Wang Yibo, Wang Jizheng, Yang Xu, Song Xiaodong, Xin Ying, Liu Zhe, Hui Rutai

Abstract excerpt

Mitogen-activated protein kinase kinase 7 (MKK7) induces cardiac hypertrophy by activating the c-Juns NH2-terminal kinases (JNK). It has been reported that growth arrest and DNA-damage-inducible beta (GADD45Beta) binds to MKK7 directly and blocks its catalytic activity, mediates the inhibition of JNK signaling. However, the potential role of GADD45Beta on cardiac hypertrophy has not been investigated. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation
Share to Atrial Natriuretic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomegaly

Share to Enhancer Elements, Genetic

Share to Genes, Reporter

Share to Myocytes, Cardiac

Share to RNA, Small Interfering

Share to Transcription, Genetic

Source

Identifiers

PMID: 18515079
DOI: 10.1016/j.bbrc.2008.05.122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy.PMID 18515079Read ↗

MYH7 R453C induced cardiac remodelling via activating TGF-β/Smad2/3, ERK1/2 and Nox4/ROS/NF-κB signalling pathways.Semantic proximity Read ↗

Recent discoveries of the role of histone modifications and related inhibitors in pathological cardiac hypertrophySemantic proximity Read ↗

Critical Role of miR-130b-5p in Cardiomyocyte Proliferation and Cardiac Repair in Mice After Myocardial InfarctionSemantic proximity Read ↗

miR133a regulates cardiomyocyte hypertrophy in diabetesSemantic proximity Read ↗

MSK-mediated phosphorylation of Histone 3 Ser28 couples MAPK signaling with early gene induction and cardiac hypertrophySemantic proximity Read ↗

AKT-mTOR Signaling-Mediated Rescue of PRKAG2 R302Q Mutant-Induced Familial Hypertrophic Cardiomyopathy by Treatment with β-AR Blocker MetoprololSemantic proximity Read ↗

Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac HypertrophySemantic proximity Read ↗

Unmusking of Protein Phosphatase 2 Regulatory Subunit B as a crucial factor in the development and progression of dilated cardiomyopathySemantic proximity Read ↗

MiR‐26a‐5p alleviates cardiac hypertrophy and dysfunction via targeting ADAM17Semantic proximity Read ↗

CAMK2D causes heart failure in mice with RBM20 cardiomyopathy.Semantic proximity Read ↗

I-κB kinase-ε deficiency attenuates the development of Doxorubicin-induced dilated cardiomyopathySemantic proximity Read ↗

Regulation of the Balance between Concentric and Eccentric Cardiac Hypertrophy by a CDC14A-KMT5A Signaling PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.