Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of cyclooxygenase-2 expression by cAMP response element and mRNA stability in a human airway epithelial cell line exposed to zinc.

Toxicology and applied pharmacology - 1 Sept 2008

Wu Weidong, Silbajoris Robert A, Cao Dongsun, Bromberg Philip A, Zhang Qiao, Peden David B, Samet James M

Abstract excerpt

Exposure to zinc-laden particulate matter in ambient and occupational settings has been associated with proinflammatory responses in the lung. Cyclooxygenase 2-derived eicosanoids are important modulators of airway inflammation. In this study, we characterized the transcriptional and posttranscriptional events that regulate COX-2 expression in a human bronchial epithelial cell line BEAS-2B exposed to Zn2+. Zn2+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Bronchi

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to Cyclooxygenase 2

Share to NF-kappa B

Share to RNA Stability

Share to Transcription, Genetic

Source

Identifiers

PMID: 18513776
DOI: 10.1016/j.taap.2008.04.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Regulation of cyclooxygenase-2 expression by cAMP response element and mRNA stability in a human airway epithelial cell line exposed to zinc.PMID 18513776Read ↗

Transcriptional Regulation of Cyclooxygenase 2 by Bradykinin and Interleukin-1β in Human Airway Smooth Muscle Cells: Involvement of Different Promoter Elements, Transcription Factors, and Histone H4 AcetylationSemantic proximity Read ↗

Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells.Semantic proximity Read ↗

Effects of zinc deficiency on immune functionsSemantic proximity Read ↗

Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways.Semantic proximity Read ↗

The DNA Binding Activity of Metal Response Element-binding Transcription Factor-1 Is Activated in vivo and in Vitro by Zinc, but Not by Other Transition MetalsSemantic proximity Read ↗

An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T LymphocytesSemantic proximity Read ↗

Regulatory properties and cellular redistribution of zinc during macrophage differentiation of human leukemia cells.Semantic proximity Read ↗

Treatment of human T cells with bisperoxovanadium phosphotyrosyl phosphatase inhibitors leads to activation of cyclooxygenase-2 gene.Semantic proximity Read ↗

Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro.Semantic proximity Read ↗

Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.