Article
Lack of cytoplasmic ERK activation is an independent adverse prognostic factor in primary cutaneous melanoma.
The Journal of investigative dermatology - 1 Nov 2008
Jovanovic Braslav, Kröckel Doris, Linden Diana, Nilsson Bo, Egyhazi Suzanne, Hansson Johan
Abstract excerpt
The aim of this study was to estimate the impact on survival of NRAS and BRAF mutations and activation of Akt and extracellular signal-regulated kinase (ERK) in primary melanomas. A cohort of 57 primary cutaneous T1-2 melanoma tumors was analyzed. Mutation frequency for both genes was 61% (NRAS 26% and BRAF 39%). In a univariate analysis, shorter overall survival was associated with the presence of ulceration...
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