Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.

FEBS letters - 25 Jun 2008

Winton Matthew J, Van Deerlin Vivianna M, Kwong Linda K, Yuan Wuxing, Wood Elisabeth McCarty, Yu Chang-En, Schellenberg Gerard D, Rademakers Rosa, Caselli Richard, Karydas Anna, Trojanowski John Q, Miller Bruce L, Lee Virginia M-Y

Abstract excerpt

TAR DNA-binding protein-43 (TDP-43) is a highly conserved, ubiquitously expressed nuclear protein that was recently identified as the disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). Pathogenic TDP-43 gene (T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Nucleus

Share to Cytoplasm

Share to Dementia

Share to Nuclear Localization Signals

Share to Solubility

Source

Open in PubMed Open full text

Identifiers

PMID: 18505686
DOI: 10.1016/j.febslet.2008.05.024
PMCID: PMC2478749

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18505686-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.PMID 18505686Read ↗

Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitroSemantic proximity Read ↗

RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathySemantic proximity Read ↗

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.Semantic proximity Read ↗

Unraveling the toxic effects mediated by the neurodegenerative disease-associated S375G mutation of TDP-43 and its S375E phosphomimetic variant.Semantic proximity Read ↗

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicitySemantic proximity Read ↗

The role of TDP-43 mislocalization in amyotrophic lateral sclerosisSemantic proximity Read ↗

Molecular, functional, and pathological aspects of TDP-43 fragmentationSemantic proximity Read ↗

Functional Significance of TDP-43 Mutations in Disease.Semantic proximity Read ↗

TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA.Semantic proximity Read ↗

[TDP-43 proteinopathies: ALS and frontotemporal dementias].Semantic proximity Read ↗

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).Semantic proximity Read ↗

Interaction with Polyglutamine Aggregates Reveals a Q/N-rich Domain in TDP-43Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.