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Article

Acquired resistance to trimethoprim-sulfamethoxazole during Whipple disease and expression of the causative target gene.

The Journal of infectious diseases - 1 Jul 2008

Bakkali Nawal, Fenollar Florence, Biswas Silpak, Rolain Jean-Marc, Raoult Didier

Abstract excerpt

BACKGROUND: Whipple disease is a chronic infection caused by Tropheryma whipplei. Trimethoprim-sulfamethoxazole is recommended for treatment of Whipple disease but is associated with treatment failure. T. whipplei is resistant in vitro to trimethoprim, because the gene targeted by this agent is missing. METHODS: A patient experienced clinical failure during treatment with trimethoprim-sulfamethoxazole. The gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18500934
DOI: 10.1086/588706

Genes

DHPS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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