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Molecular Evaluation of Antibiotic Susceptibility: Tropheryma whipplei Paradigm

22 Apr 2003

Abstract excerpt

Tropheryma whipplei, the agent of Whipple's disease, grows fastidiously only in cell cultures without plaque production, and only three strains have been passaged. The formation of bacterial clumps in the supernatant precludes enumeration of viable bacteria and MIC determination. We evaluated the bacteriostatic effects of fluoroquinolones against two T. whipplei isolates by measuring the inhibition of the DNA...

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PMID: 12709337
DOI: 10.1128/aac.47.5.1658-1664.2003

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