Hairpin-mediated down-regulation of the urea cycle enzyme argininosuccinate lyase in Agaricus bisporus.

doi:10.1016/j.mycres.2008.01.009

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Article

Hairpin-mediated down-regulation of the urea cycle enzyme argininosuccinate lyase in Agaricus bisporus.

Mycological research - 1 Jun 2008

Eastwood Daniel C, Challen Michael P, Zhang Cunjin, Jenkins Huw, Henderson Janey, Burton Kerry S

Abstract excerpt

A double-stranded (ds) RNA hairpin-mediated down-regulation system was developed for the cultivated mushroom Agaricus bisporus, and the role of the urea cycle enzyme argininosuccinate lyase (asl) in mushroom post-harvest development was investigated. Hairpin expression vectors were constructed to initiate down-regulation of asl and introduced into A. bisporus by Agrobacterium tumefaciens-mediated transformation....

Topics

Agaricus
Argininosuccinate Lyase
Base Pairing
Down-Regulation
Fungal Proteins
Gene Dosage
Gene Expression Regulation, Fungal
Genetic Vectors
Phenotype
RNA Interference
RNA, Double-Stranded
RNA, Small Interfering
Transformation, Genetic
Urea

Source

Open in PubMed

Identifiers

PMID: 18499425
DOI: 10.1016/j.mycres.2008.01.009

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