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Short hairpin RNA-mediated knockdown of protein expression in Entamoeba histolytica

17 Feb 2009

Abstract excerpt

BACKGROUND: Entamoeba histolytica is an intestinal protozoan parasite of humans. The genome has been sequenced, but the study of individual gene products has been hampered by the lack of the ability to generate gene knockouts. We chose to test the use of RNA interference to knock down gene expression in Entamoeba histolytica. RESULTS: An episomal vector-based system, using the E. histolytica U6 promoter to drive...

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PMID: 19222852
DOI: 10.1186/1471-2180-9-38

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