Article
PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit.
Neurosurgery - 1 Apr 2008
Tanriover Gamze, Boylan Arianne J, Diluna Michael L, Pricola Katie L, Louvi Angeliki, Gunel Murat
Abstract excerpt
OBJECTIVE: Mutations in the programmed cell death 10 gene, PDCD10, cause the autosomal-dominant familial cerebral cavernous malformation 3 (CCM3). Little is known about the function of this gene in disease pathogenesis. METHODS: As a first step, we analyzed the messenger ribonucleic acid (mRNA) e...
Topics
- Animals
- Apoptosis Regulatory Proteins
- Cerebral Arteries
- Endothelium, Vascular
- Humans
- Intracranial Arteriovenous Malformations
- Membrane Proteins
- Mice
- Mutation
- Proto-Oncogene Proteins
- Tissue Distribution