Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit.

Neurosurgery - 1 Apr 2008

Tanriover Gamze, Boylan Arianne J, Diluna Michael L, Pricola Katie L, Louvi Angeliki, Gunel Murat

Abstract excerpt

OBJECTIVE: Mutations in the programmed cell death 10 gene, PDCD10, cause the autosomal-dominant familial cerebral cavernous malformation 3 (CCM3). Little is known about the function of this gene in disease pathogenesis. METHODS: As a first step, we analyzed the messenger ribonucleic acid (mRNA) expression of CCM3 in the embryonic and postnatal mouse brain by in situ hybridization. We generated and characterized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CCM2 gene

Share to Membrane Proteins

Share to Mutation

Share to Proto-Oncogene Proteins

Share to Tissue Distribution

Source

Identifiers

PMID: 18496199
DOI: 10.1227/01.neu.0000318179.02912.ca

Genes

PDCD10
CCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit.PMID 18496199Read ↗

The multifaceted PDCD10/CCM3 geneSemantic proximity Read ↗

Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology.Semantic proximity Read ↗

Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular DevelopmentSemantic proximity Read ↗

Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations.Semantic proximity Read ↗

Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformationsSemantic proximity Read ↗

Molecular Genetic Features of Cerebral Cavernous Malformations (CCM) Patients: An Overall View from Genes to Endothelial Cells.Semantic proximity Read ↗

Surveying genetic variants and molecular phylogeny of cerebral cavernous malformation gene, CCM3/PDCD10.Semantic proximity Read ↗

Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3.Semantic proximity Read ↗

Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and PericytesSemantic proximity Read ↗

Comprehensive CCM3 Mutational Analysis in Patients with Syndromic Cerebral Cavernous MalformationSemantic proximity Read ↗

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.Semantic proximity Read ↗

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.