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Article

A critical beta6-beta7 loop in the pleckstrin homology domain of ceramide kinase.

The Biochemical journal - 1 Dec 2006

Rovina Philipp, Jaritz Markus, Höfinger Siegfried, Graf Christine, Dévay Piroska, Billich Andreas, Baumruker Thomas, Bornancin Frédéric

Abstract excerpt

CerK (ceramide kinase) produces ceramide 1-phosphate, a sphingophospholipid with recognized signalling properties. It localizes to the Golgi complex and fractionates essentially between detergent-soluble and -insoluble fractions; however, the determinants are unknown. Here, we made a detailed mutagenesis study of the N-terminal PH domain (pleckstrin homology domain) of CerK, based on modelling, and identified key...

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Identifiers

PMID: 16872273
DOI: 10.1042/BJ20060316
PMCID: PMC1652822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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