Structure and organization of the hepatitis C virus genome isolated from human carriers

doi:10.1128/jvi.65.3.1105-1113.1991

Article

Structure and organization of the hepatitis C virus genome isolated from human carriers

1 Mar 1991

Abstract excerpt

Hepatitis C virus (HCV) is a major causative agent of posttransfusion non-A, non-B hepatitis, which often develops into malignant chronic diseases, including liver cirrhosis and hepatocellular carcinoma. We have cloned from human carriers overlapping cDNAs (9,416 bp) covering the entire coding region of the HCV genome. The latter encodes a 3,010-amino-acid polyprotein. In addition, there are 332 and 54 bases of...

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