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Article

Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.

Cellular signalling - 1 Aug 2008

Guo Changsheng, Degnin Catherine R, Laederich Melanie B, Lunstrum Gregory P, Holden Paul, Bihlmaier Jeanie, Krakow Deborah, Cho Yoon-Jae, Horton William A

Abstract excerpt

Thanatophoric dysplasia is a member of the achondroplasia family of human skeletal dysplasias, which result from FGFR3 mutations that exaggerate this receptor's inhibitory influence on chondrocyte proliferation and differentiation in the skeletal growth plate. We have previously reported that defective lysosomal degradation of activated receptor contributes to the gain-of-function of the mutant FGFR3. We now...

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Source

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Identifiers

PMID: 18485666
DOI: 10.1016/j.cellsig.2008.04.001
PMCID: PMC2675614

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.PMID 18485666Read ↗

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasiaSemantic proximity Read ↗

Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias.Semantic proximity Read ↗

FGFR3 biology and skeletal disease.Semantic proximity Read ↗

Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells.Semantic proximity Read ↗

FGFR3 targeting strategies for achondroplasia.Semantic proximity Read ↗

Typical achondroplasia secondary to a unique insertional variant of FGFR3 with in vitro demonstration of its effect on FGFR3 function.Semantic proximity Read ↗

Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.Semantic proximity Read ↗

FGFR3-related condition: a skeletal dysplasia with similarities to thanatophoric dysplasia and SADDAN due to Lys650Met.Semantic proximity Read ↗

A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene.Semantic proximity Read ↗

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.Semantic proximity Read ↗

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia.Semantic proximity Read ↗

Mutant FGFR3 associated with SADDAN disease causes cytoskeleton disorganization through PLCγ1/Src-mediated paxillin hyperphosphorylation.Semantic proximity Read ↗

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