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Article

Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.

Cellular signalling - 1 Aug 2008

Guo Changsheng, Degnin Catherine R, Laederich Melanie B, Lunstrum Gregory P, Holden Paul, Bihlmaier Jeanie, Krakow Deborah, Cho Yoon-Jae, Horton William A

Abstract excerpt

Thanatophoric dysplasia is a member of the achondroplasia family of human skeletal dysplasias, which result from FGFR3 mutations that exaggerate this receptor's inhibitory influence on chondrocyte proliferation and differentiation in the skeletal growth plate. We have previously reported that def...

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Identifiers

PMID: 18485666
DOI: 10.1016/j.cellsig.2008.04.001
PMCID: PMC2675614

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18485666-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.PMID 18485666Read ↗

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Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.Semantic proximity Read ↗

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