Article
A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia.
Human molecular genetics - 15 Dec 2012
Jin Min, Yu Ying, Qi Huabing, Xie Yangli, Su Nan, Wang Xiaofeng, Tan Qiaoyan, Luo Fengtao, Zhu Ying, Wang Quan, Du Xiaolan, Xian Cory J, Liu Peng, Huang Haiyang, Shen Yue, Deng Chu-Xia, Chen Di, Chen Lin
Abstract excerpt
Gain-of-function mutations in fibroblast growth factor receptor-3 (FGFR3) lead to several types of human skeletal dysplasia syndromes including achondroplasia, hypochondroplasia and thanatophoric dysplasia (TD). Currently, there are no effective treatments for these skeletal dysplasia diseases. In this study, we screened, using FGFR3 as a bait, a random 12-peptide phage library and obtained 23 positive clones...
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