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Article

VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2008

Torkko Kathleen C, van Bokhoven Adrie, Mai Phoung, Beuten Joke, Balic Ivana, Byers Tim E, Hokanson John E, Norris Jill M, Barón Anna E, Lucia M Scott, Thompson Ian M, Leach Robin J

Abstract excerpt

PURPOSE: Vitamin D and dihydrotestosterone pathways interact to promote the growth of prostatic tissue. The nuclear vitamin D receptor (VDR) moderates the actions of vitamin D. 5alpha-Reductase type II (SRD5A2) codes for the enzyme that converts testosterone to dihydrotestosterone in the prostate...

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Share to 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

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Share to Receptors, Calcitriol

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Source

Identifiers

PMID: 18483391
DOI: 10.1158/1078-0432.CCR-07-4894

Genes

CDX2
VDR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18483391-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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