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Article

Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.

Cancer research - 15 May 2008

Mehra Rohit, Tomlins Scott A, Yu Jianjun, Cao Xuhong, Wang Lei, Menon Anjana, Rubin Mark A, Pienta Kenneth J, Shah Rajal B, Chinnaiyan Arul M

Abstract excerpt

Recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS transcription factor family members ERG, ETV1, and ETV4 have been identified as a critical event in prostate cancer development. In this study, we characterized the prevalence and diversity of these rearrangements in h...

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Topics

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Share to In Situ Hybridization, Fluorescence
Share to Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Prostatic Neoplasms

Share to Proto-Oncogene Proteins c-ets

Share to Serine Endopeptidases

Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 18483239
DOI: 10.1158/0008-5472.CAN-07-6154
PMCID: PMC2677168

Genes

TMPRSS2
ERG
ETV1
ETV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18483239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.PMID 18483239Read ↗

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