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Article

Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.

Cancer research - 15 May 2008

Mehra Rohit, Tomlins Scott A, Yu Jianjun, Cao Xuhong, Wang Lei, Menon Anjana, Rubin Mark A, Pienta Kenneth J, Shah Rajal B, Chinnaiyan Arul M

Abstract excerpt

Recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS transcription factor family members ERG, ETV1, and ETV4 have been identified as a critical event in prostate cancer development. In this study, we characterized the prevalence and diversity of these rearrangements in hormone-refractory metastatic prostate cancer. We used a fluorescence in situ hybridization (FISH) split probe strategy...

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Topics

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Share to Androgens
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasm Metastasis

Share to Oncogene Proteins, Fusion

Share to Prostatic Neoplasms

Share to Proto-Oncogene Proteins c-ets

Share to Serine Endopeptidases

Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 18483239
DOI: 10.1158/0008-5472.CAN-07-6154
PMCID: PMC2677168

Genes

TMPRSS2
ERG
ETV1
ETV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.PMID 18483239Read ↗

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