Article
The effects of inhibitors of topoisomerase II and quinacrine on ultraviolet-light-induced DNA incision in normal and xeroderma pigmentosum fibroblasts.
Journal of cancer research and clinical oncology - 1 Jan 1991
Thielmann H W, Popanda O, Edler L
Abstract excerpt
The aim of our work was to investigate whether DNA topoisomerase II participates in the repair-specific incision of UV-irradiated genomic DNA. Therefore, the influence upon DNA incision of the topoisomerase II inhibitors (nalidixic and oxolinic acid, novobiocin and coumermycin A1) as well as the...
Topics
- Aminocoumarins
- Cell Cycle
- Cells, Cultured
- Coumarins
- DNA
- DNA Damage
- DNA Repair
- DNA Topoisomerases, Type II
- Dose-Response Relationship, Drug
- Fibroblasts
- Genetic Variation
- Humans
- Nalidixic Acid
- Novobiocin
- Oxolinic Acid
- Quinacrine
- Topoisomerase II Inhibitors
- Ultraviolet Rays