Article
Brief report: no association between premorbid adjustment in adult-onset schizophrenia and genetic variation in Dysbindin.
Journal of autism and developmental disorders - 1 Nov 2008
Schirmbeck Frederike, Georgi Alexander, Strohmaier Jana, Schmael Christine, Boesshenz Katja V, Mühleisen Thomas W, Herms Stefan, Hoffmann Per, Jamra Rami Abou, Schumacher Johannes, Maier Wolfgang, Propping Peter, Nöthen Markus M, Cichon Sven, Rietschel Marcella, Schulze Thomas G
Abstract excerpt
Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in...
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